ABSTRACT
Background: Telithromycin is a new ketolide antimicrobial, that can be useful for the treatment of respiratory infections. Aim: To compare in vitro activity of telithromycin against respiratory pathogens, isolated in outpatient clinics. Material and methods: Two hundred eighty strains isolated from patients with respiratory infections, were studied. The strains studied were S pneumoniae, penicillin sensitive (SPNS:57); intermediate (SPNI:35), resistant (SPNR:25); S pyogenes (SP:57); H influenzae (HIN 51); M catarrhalis (MC:25) and S aureus meticillin sensitive (SAUS:30). Minimal inhibitory concentration (MIC) by broth microdilution was studied for telitrhomycin and levofloxacin in all strains. Other antimicrobials studied, but not in all strains were erythromycin, clindamycin, trimetoprim sulphamethoxazole, oxacillin, amoxicillin-clavulanic acid and cefuroxime. Results: All strains were sensible to telithromycin at a concentration ¡4 µg/ml. MIC 90 and its range for SPNS was 0.03 µg/ml (¡0.004-0.12), for SPNI was 0.03 µg/ml (¡0.004-025), for SPNR was 0.06 µg/ml (¡0.004-0.25), for HIN was 2 µg/ml (0.12-4), for SP was 0.5 µg/ml (¡0.004-2), for MC was 0.5 µg/ml (0.06-2) and for SAU was 0.25 µg/ml (0.06-0.25). Conclusions: All studied pathogens were sensible to telithromycin in vitro. This antimicrobial is an alternative for the treatment of community acquired respiratory infections.
Subject(s)
Humans , Anti-Bacterial Agents/pharmacology , Respiratory Tract Infections/drug therapy , Community-Acquired Infections/drug therapy , Streptococcus pneumoniae , Streptococcus pyogenesABSTRACT
A toxonomic study of 82 strains of Staphylococci and 6 reference samples isolated from clinical cases was carried out. Results of 47 phenotype tests were submitted to a numerical analysis using the similarity coefficient of Sokal and Michener and a grouping technique (UPGMA). Based on a 75 similarity level, 4 phenons were identified. 37 strains identified as S aureus were grouped in phenon A; 32 strains of S hominis in phenon B; 5 strains of S epidermidis in phenon C and 8 strains of S ssp in phenon D
Subject(s)
Staphylococcus/classification , In Vitro Techniques , Specimen Handling , Staphylococcus/isolation & purification , Cross Infection , Bacteriological TechniquesABSTRACT
Se presenta una niña de 14 años con actinomicosis torácica. Se destaca la rara incidencia de esta enfermedad en la edad pediátrica y las dificultades para hacer el diagnóstico. La presencia de una lesión pulmonar de larga evolución, junto a lesiones osteomielíticas de varias costillas y posterior fistulización a la pared costal, con eliminación de los característicos "gránulos de azufre" fueron los elementos claves para sospechar la causa de la enfermedad. Se confirmó el diagnóstico por estudio bacteriológico e histológico. La paciente se trató con dosis altas de penicilina, evolucionando en forma favorable